A topical gel made from blood pressure drugs
A new topical gel made by a class of common blood pressure drugs that block inflammation pathways speeds the healing of chronic skin wounds in mice and pigs.
The gel used in treatment-resistant skin wounds among diabetics and others, particularly older adults.
“The FDA has not issued any new drug approval for wound healing in the past 10 years,” says, Peter Abadir, M.D., associate professor of medicine at the Johns Hopkins University School of Medicine. In some times chronic wounds increase the risk of infection and tissue breakdown.
According to study, the skin’s renin-angiotensin system (RAS) system is abnormally regulated in diabetics and older adults.
However, researches experimented with gel formulations of angiotensin II receptors, Losartan, valsartan, a long-standing class of drugs treat hypertension. The drugs block RAS and increase wound blood flow, and also increase wound tissue level of the drugs that promote faster healing.
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